Article

Evidence for Deleterious Antigenic Imprinting in SARS-CoV-2 Immune Response

2021-05-24

Abstract excerpt

A previous report demonstrated the strong association between the presence of antibodies binding to an epitope region from SARS-CoV-2 nucleocapsid, termed Ep9, and COVID-19 disease severity. Patients with anti-Ep9 antibodies (Abs) had hallmarks of antigenic imprinting (AIM), including early IgG upregulation and cytokine-associated injury. Thus, the immunological memory of a previous infection was hypothesized to d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51eea8a3-1227-513a-8e17-aed4401cbeef
DOI: 10.1101/2021.05.21.445201

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evidence for Deleterious Antigenic Imprinting in SARS-CoV-2 Immune ResponseDOI 10.1101/2021.05.21.445201Read

Immune imprinting of SARS-CoV-2 responses: changing first immune impressionsSemantic proximity Read

Investigation of Immunoreactivity Profiles and Epitope Landscape in Divergent COVID-19 Trajectories and SARS-CoV-2 Variants.Semantic proximity Read

Predominance of Distinct Autoantibodies in Response to SARS-CoV-2 InfectionSemantic proximity Read

First Impressions Matter: Immune Imprinting and Antibody Cross-Reactivity in Influenza and SARS-CoV-2Semantic proximity Read

Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variantsSemantic proximity Read

Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variantsSemantic proximity Read

Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individualsSemantic proximity Read

Diverse Functional Autoantibodies in Patients with COVID-19Semantic proximity Read

Pre-Existing Cellular Immunity to SARS-CoV-2 Through an Immunodominant EpitopeSemantic proximity Read

Repeated COVID-19 vaccine boosters elicit variant-specific memory B cells in humansSemantic proximity Read

Deciphering the IgG Idiotype Network Through Proteomic Analysis of Potential Targets in SARS ‐ CoV ‐2‐Induced Immune ResponsesSemantic proximity Read

The immune response to SARS-CoV-2 as a recall response susceptible to immune imprinting: a prospective cohort studySemantic proximity Read