Article

The amino acid residue in position 163 of canine PrP <sup>C</sup> is critical to the exceptional resistance of dogs to prion infections: evidence from transgenic mouse models

2019-10-10

Abstract excerpt

<h4>ABSTRACT</h4> Unlike other species, such as cattle, cats or humans, prion disease has never been described in dogs, even though they were similarly exposed to the bovine spongiform encephalopathy (BSE) agent. This resistance prompted a thorough analysis of the canine PRNP gene and the presence of a negatively charged amino acid residue in position 163 was readily identified as potentially fundamental as it d...

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Literature Corpus work: 519b5d81-1119-50b5-9ded-93b1b4a120f1
DOI: 10.1101/800698

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