Article

Unraveling the Comedone Switch through Single-Cell Resolution of Human Acne Lesions

2026-07-16

Abstract excerpt

<h4>ABSTRACT</h4> Acne vulgaris is one of the most prevalent inflammatory skin diseases worldwide, yet the molecular events initiating comedogenesis remain poorly understood. The comedone switch hypothesis proposes that acne originates from an imbalance in lineage commitment within the junctional zone of the pilosebaceous unit, promoting infundibular differentiation at the expense of sebaceous gland maintenance....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 516b4f27-c7a8-5697-a68b-9a98dcb3e295
DOI: 10.64898/2026.07.09.737640

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unraveling the Comedone Switch through Single-Cell Resolution of Human Acne LesionsDOI 10.64898/2026.07.09.737640Read

Development of an Integrated Single-Cell and Spatial Transcriptomics Atlas of Healthy Human Skin Focusing on the Pilosebaceous UnitSemantic proximity Read

Single-cell transcriptomics in dermatologySemantic proximity Read

Spatial and Single-Cell Transcriptomics Reveal Keratinocytes as Key Players in Vulvar Lichen Sclerosus PathogenesisSemantic proximity Read

Hair follicle stem cell fate supports distinct clinical endotypes in <i>Hidradenitis Suppurativa</i>Semantic proximity Read

Somatic Mutations in NEK9 Cause Nevus Comedonicus.Semantic proximity Read

Multimodal Human Scalp Atlas Defines Cell Landscape and Lineage Architecture In SituSemantic proximity Read

Challenges and Opportunities for the Translation of Single-Cell RNA Sequencing Technologies to DermatologySemantic proximity Read

What does acne genetics teach us about disease pathogenesis?Semantic proximity Read

Defining Epidermal Stem Cell Fate Infidelity and Immunogenicity in Hidradenitis Suppurativa at the Single-Cell ResolutionSemantic proximity Read

Homeostasis of the sebaceous gland and mechanisms of acne pathogenesisSemantic proximity Read

Hair follicle stem cell fate supports distinct clinical endotypes in hidradenitis suppurativa.Semantic proximity Read

Single-Cell and Spatial Transcriptomic Analysis of Human Skin Delineates Intercellular Communication and Pathogenic CellsSemantic proximity Read