Article

A Missense Mutation in Human CHD4 Causes Ventricular Noncompaction by Repressing ADAMTS1-mediated Trabeculation Cessation

2022-09-12

Abstract excerpt

<h4>Background</h4> Left ventricular noncompaction (LVNC) is a prevalent cardiomyopathy associated with excessive trabeculation and thin compact myocardium. Patients with LVNC are vulnerable to cardiac dysfunction and at high risk of sudden death. Although sporadic and inherited mutations in cardiac genes are implicated in LVNC, understanding of the mechanisms responsible for human LVNC is limited. <h4>Methods</h...

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Literature Corpus work: 5111eade-1ff7-557c-8e17-d373f0cf80c2
DOI: 10.1101/2022.09.12.507607

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