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Article

Comprehensive mutational characterization of the calcium-sensing STIM1 EF-hand reveals residues essential for structure and function.

Genetics - 8 Oct 2025

Kamath Nisha D, Matreyek Kenneth A

Abstract excerpt

Calcium signaling is a fundamental molecular means of cellular regulation. Store operated calcium entry (SOCE) is a major intracellular signaling module, wherein calcium release from the endoplasmic reticulum (ER) triggers transmembrane STIM1 proteins to conformationally shift and oligomerize to prompt calcium influx from the extracellular environment. STIM1 senses ER calcium concentrations with its canonical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40737484
DOI: 10.1093/genetics/iyaf146
PMCID: PMC12505291

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Comprehensive mutational characterization of the calcium-sensing STIM1 EF-hand reveals residues essential for structure and function.PMID 40737484Read ↗

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