Article

A Tissue-Bioengineering Strategy for Modeling Rare Human Kidney Diseases <i>In Vivo</i>

2021-10-20

Abstract excerpt

<h4>ABSTRACT</h4> The lack of animal models for certain human diseases precludes our understanding of disease mechanisms and our ability to test new therapies in vivo . Here we generated kidney organoids from Tuberous Sclerosis Complex (TSC) patient-derived-hiPSCs to recapitulate a rare kidney tumor called angiomylipoma (AML). Organoids derived from TSC2 -/- hiPSCs but not from isogenic TSC2 +/- or TSC2 +/+ h...

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Literature Corpus work: 4fc65ee6-b279-56bf-ba0a-b04feadf61cd
DOI: 10.1101/2021.10.20.465120

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