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Article

New developments in the genetics and pathogenesis of tumours in tuberous sclerosis complex.

The Journal of pathology - 1 Jan 2017

Lam Hilaire C, Nijmeh Julie, Henske Elizabeth P

Abstract excerpt

In just the past 5 years, dramatic changes have occurred in the clinical management of tuberous sclerosis complex (TSC). Detailed knowledge about the role of the TSC proteins in regulating the activity of the mammalian target of rapamycin complex 1 (mTORC1) underlies this paradigm-shifting progress. Advances continue to be made in understanding the genetic pathogenesis of the different tumours that occur in TSC,...

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Identifiers

PMID: 27753446
DOI: 10.1002/path.4827
PMCID: PMC5167646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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