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Article

Suppressor mutations in Mecp2-null mice implicate the DNA damage response in Rett syndrome pathology.

Genome research - 1 Apr 2020

Enikanolaiye Adebola, Ruston Julie, Zeng Rong, Taylor Christine, Schrock Marijke, Buchovecky Christie M, Shendure Jay, Acar Elif, Justice Monica J

Abstract excerpt

Mutations in X-linked methyl-CpG-binding protein 2 (MECP2) cause Rett syndrome (RTT). To identify functional pathways that could inform therapeutic entry points, we carried out a genetic screen for secondary mutations that improved phenotypes in Mecp2/Y mice after mutagenesis with N-ethyl-N-nitrosourea (ENU). Here, we report the isolation of 106 founder animals that show suppression of Mecp2-null traits from...

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Identifiers

PMID: 32317254
DOI: 10.1101/gr.258400.119
PMCID: PMC7197480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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