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Article

Low Efficiency of Homology-Independent Targeted Integration for CRISPR/Cas9 Correction in the Vicinity of SLC26A4 c.919–2A>G Variant

2024-06-20

Abstract excerpt

<title>Abstract</title> <p>Recessive variants of <italic>SLC26A4</italic> are a common cause of hereditary hearing impairment and are responsible for non-syndromic enlarged vestibular aqueducts and Pendred syndrome. Patients with bi-allelic <italic>SLC26A4</italic> variants often suffer from fluctuating hearing loss and recurrent vertigo, ultimately leading to severe to profound hearing impairment. However, there...

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Literature Corpus work
4f4acf26-eaf1-575b-9a01-58d22b93e872
DOI
10.21203/rs.3.rs-4244945/v1
Open publication

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