Back to search

Article

Ruscogenin alleviates intestinal bleeding and blood flow induced by Dasatinib through ROCK/MLC pathway

2021-08-12

Abstract excerpt

<title>Abstract</title> <p>As a second-generation broad-spectrum tyrosine kinase inhibitor, Dasatinib has the antitumor effect of inhibiting tyrosine kinases such as BCR-ABL and SRC. It is mainly used to treat chronic and acute patients with chronic myelogenous leukemia. However, Dasatinib has many side effects, including gastrointestinal bleeding, respiratory infections, and renal failure, and effective means to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4f2f6b43-cbe1-5aaa-8012-29b4054ba21f
DOI
10.21203/rs.3.rs-207273/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Ruscogenin alleviates intestinal bleeding and blood flow induced by Dasatinib through ROCK/MLC pathwayDOI 10.21203/rs.3.rs-207273/v1
Ruscogenin Alleviates Intestinal Bleeding and Blood Flow Induced by Dasatinib&nbsp;through ROCK/MLC PathwaySemantic proximity
Aspirin reduces Ponatinib-induced cardiovascular toxic phenotypes and death in zebrafish.Semantic proximity
A Narrative Review on Adverse Effects of Dasatinib With a Focus on Pharmacotherapy of Dasatinib-Induced Pulmonary ToxicitiesSemantic proximity
Mechanisms of lower gastrointestinal toxicity caused by tyrosine kinase inhibitorsSemantic proximity
Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signaling pathwaySemantic proximity
The frequency of cardiovascular events caused by second-generation tyrosine kinase inhibitors may depend on the treatment intensity in patients with chronic myeloid leukemiaSemantic proximity
Ponatinib reduces viability, migration, and functionality of human endothelial cells.Semantic proximity
Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension.Semantic proximity
Select a neighboring publication to make it the new centre.