Article

Transformer 2β Regulates the Alternative Splicing of Cell Cycle Regulator Genes to Promote Ovarian Cancer Cell Progression

2021-09-14

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Late-stage ovarian cancer (OV) has a poor prognosis and a high metastasis rate, but the underlying molecular mechanism is ambiguous. RNA binding proteins (RBPs) play important roles in posttranscriptional regulation in the contexts of neoplasia and tumor metastasis. <bold>Results:</bold> In this study, we explored the molecular functions of a canonical RBP, TRA2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4ebbef3c-091d-5d2f-bcd4-995e1e0f77f3
DOI: 10.21203/rs.3.rs-853170/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transformer 2β Regulates the Alternative Splicing of Cell Cycle Regulator Genes to Promote Ovarian Cancer Cell ProgressionDOI 10.21203/rs.3.rs-853170/v1Read

Systematic Analysis of the Relationship Between Ovarian Cancer Prognosis and Alternative SplicingSemantic proximity Read

The epigenetic factor BORIS (CTCFL) controls the androgen receptor regulatory network in ovarian cancerSemantic proximity Read

OVOL2 impairs RHO GTPase signaling to restrain mitosis and aggressiveness of Anaplastic Thyroid CancerSemantic proximity Read

A novel signature of two long non-coding RNAs in BRCA mutant ovarian cancer to predict prognosis and efficiency of chemotherapySemantic proximity Read

Role of survival-associated alternative splicing events in the prognosis of ovarian cancerSemantic proximity Read

Spatial Transcriptomic Analysis of Ovarian Cancer Precursors Reveals Reactivation of IGFBP2 during PathogenesisSemantic proximity Read

Differential Functions of Splicing Factors in Breast-Cancer Initiation and MetastasisSemantic proximity Read

Long non‐coding RNA ZEB2‐AS1 promotes the proliferation, metastasis and epithelial mesenchymal transition in triple‐negative breast cancer by epigenetically activating ZEB2Semantic proximity Read

H3K18la Facilitates TRA2A-Mediated Alternative Splicing of STIL, Suppressing Ferroptosis and Cisplatin Treatment Sensitivity in Ovarian CancerSemantic proximity Read

Survival-associated 11-AS Events Interact with the Immune Microenvironment in Ovarian CancerSemantic proximity Read

Thyroid Hormone Receptor Beta as Tumor Suppressor: Untapped Potential in Treatment and Diagnostics in Solid TumorsSemantic proximity Read

The role of TARBP2 in the development and progression of cancers.Semantic proximity Read