Article

A pro-apoptotic selection strategy enables CRISPR screening in mosquitoes and identifies Lachesin as a chikungunya virus entry factor

2026-08-04

Abstract excerpt

Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus that is transmitted primarily by Aedes aegypti and Aedes albopictus mosquitoes. CHIKV infection can result in debilitating arthritis-like symptoms in humans. While determinants of CHIKV host cell entry into mammalian cells are known, their equivalents in mosquito cells remain largely elusive. To identify CHIKV entry factors, we performed a memb...

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Literature Corpus work: 4eb7e92b-9c0c-5e43-9493-b246515d4f26
DOI: 10.64898/2026.07.31.742019

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