Article

Genetic hypogonadal (Gnrh1 <sup>hpg</sup> ) mouse model uncovers influence of reproductive axis on maturation of the gut microbiome during puberty

2024-07-02

Abstract excerpt

<h4>ABSTRACT</h4> The gut microbiome plays a key role in human health and gut dysbiosis is linked to many sex-specific diseases including autoimmune, metabolic, and neurological disorders. Activation of the hypothalamic-pituitary-gonadal (HPG) axis during puberty leads to sexual maturation and development of sex differences through the action of gonadal sex steroids. While the gut microbiome also undergoes sex di...

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Literature Corpus work: 4eb60896-66f4-5cf2-9d4b-d32d10482509
DOI: 10.1101/2024.07.01.601610

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