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StemSC: a cross-dataset human stemness index for single-cell samples

21 Mar 2022

Abstract excerpt

BACKGROUND: Stemness is defined as the potential of cells for self-renewal and differentiation. Many transcriptome-based methods for stemness evaluation have been proposed. However, all these methods showed low negative correlations with differentiation time and can't leverage the existing experimentally validated stem cells to recognize the stem-like cells. METHODS: Here, we constructed a stemness index for...

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PMID: 35313979
DOI: 10.1186/s13287-022-02803-5

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