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Article

Epigenetic silencing in Friedreich ataxia is associated with depletion of CTCF (CCCTC-binding factor) and antisense transcription.

PloS one - 19 Nov 2009

De Biase Irene, Chutake Yogesh K, Rindler Paul M, Bidichandani Sanjay I

Abstract excerpt

BACKGROUND: Over 15 inherited diseases are caused by expansion of triplet-repeats. Friedreich ataxia (FRDA) patients are homozygous for an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene. The expanded GAA triplet-repeat results in deficiency of FXN gene transcription, which is reversed via administration of histone deacetylase inhibitors indicating that transcriptional silencing is at least...

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Source

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Identifiers

PMID: 19956589
DOI: 10.1371/journal.pone.0007914
PMCID: PMC2780319

Genes

CTCF
FXN
GAA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Epigenetic silencing in Friedreich ataxia is associated with depletion of CTCF (CCCTC-binding factor) and antisense transcription.PMID 19956589Read ↗

Methylated and unmethylated epialleles support variegated epigenetic silencing in Friedreich ataxia.Semantic proximity Read ↗

Friedreich Ataxia Patient Tissues Exhibit Increased 5-Hydroxymethylcytosine Modification and Decreased CTCF Binding at the FXN LocusSemantic proximity Read ↗

Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.Semantic proximity Read ↗

Expanded GAA repeats impair FXN gene expression and reposition the FXN locus to the nuclear lamina in single cells.Semantic proximity Read ↗

Analysis of Putative Epigenetic Regulatory Elements in the FXN Genomic Locus.Semantic proximity Read ↗

Epigenetic promoter silencing in Friedreich ataxia is dependent on repeat length.Semantic proximity Read ↗

Repeat expansion affects both transcription initiation and elongation in friedreich ataxia cells.Semantic proximity Read ↗

The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues.Semantic proximity Read ↗

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