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Cyclical Regression Covariates remove the major confounding effect of cyclical developmental gene expression with strain-specific drug response in the malaria parasite <i>Plasmodium falciparum</i>

2020-04-18

Abstract excerpt

<h4>Background</h4> The cyclical nature of parasite gene expression in the intraerythrocytic development cycle (IDC) in human blood confounds the accurate detection of specific transcriptional differences due to drug resistance in Plasmodium falciparum . Here, we propose the use of cyclical regression covariates to eliminate the major confounding of developmentally driven transcriptional changes with changes due...

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Literature Corpus work
4d0c8c96-7b04-5ee2-afd3-d551d3169440
DOI
10.1101/2020.04.17.044552
Open publication

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Cyclical Regression Covariates remove the major confounding effect of cyclical developmental gene expression with strain-specific drug response in the malaria parasite <i>Plasmodium falciparum</i>DOI 10.1101/2020.04.17.044552
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