Statistical estimation of cell-cycle progression and lineage commitment in <i>Plasmodium falciparum</i> reveals a homogeneous pattern of transcription in ex vivo culture

Abstract excerpt

We have cultured Plasmodium falciparum directly from the blood of infected individuals to examine patterns of mature-stage gene expression in patient isolates. Analysis of the transcriptome of P. falciparum is complicated by the highly periodic nature of gene expression because small variations in the stage of parasite development between samples can lead to an apparent difference in gene expression values. To...

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