Article

Population immunity to clade 2.3.4.4b H5N1 is dominated by anti-neuraminidase antibodies

2026-02-12

Abstract excerpt

Clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses continue to expand geographically and across mammalian hosts, raising concern about pandemic potential. The degree and specificity of pre-existing immunity in humans are key determinants of this risk. We analyzed hemagglutinin (HA)-and neuraminidase (NA)-specific antibody responses in 300 sera collected from adults in New York City. While HA directed...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4c758c78-99ae-590f-9ad3-4880a8ff513b
DOI: 10.64898/2026.02.10.26346014

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Population immunity to clade 2.3.4.4b H5N1 is dominated by anti-neuraminidase antibodiesDOI 10.64898/2026.02.10.26346014Read

Neuraminidase-Based Cross-Protective Immunity against H5N1 Influenza Viruses in HumansSemantic proximity Read

Seasonal Influenza Exposure Elicits Functional Antibody and T-cell Responses to A(H5) Influenza Viruses in HumansSemantic proximity Read

A Panel of Human Monoclonal Antibodies for Tracking the Antigenic Evolution of Influenza H5N1 Clade 2.3.4.4bSemantic proximity Read

Assessment of cross-reactive neutralizing antibodies induction against H5N1 clade 2.3.4.4b by prior seasonal influenza immunization in retail workersSemantic proximity Read

Assessing the protective potential of H1N1 influenza virus hemagglutinin head and stalk antibodies in humansSemantic proximity Read

The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017Semantic proximity Read

H5N1 influenza binding and cell entry via human class II MHC, and blocking by cross-reactive antibodiesSemantic proximity Read

Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase.Semantic proximity Read

Targets of influenza Human T cell response are mostly conserved in H5N1Semantic proximity Read

Naturally Occurring Antibodies in Humans Can Neutralize a Variety of Influenza Virus Strains, Including H3, H1, H2, and H5Semantic proximity Read

Loss of hemagglutination ability by H3N2 influenza A virus, subclade KSemantic proximity Read

A prevalent focused human antibody response to the influenza hemagglutinin head interfaceSemantic proximity Read