Article

DIFFERENTIAL EFFICACY OF BORTEZOMIB IN SUBTYPES OF DIFFUSE LARGE B‐CELL LYMPHOMA (DLBL): a PROSPECTIVE RANDOMISED STUDY STRATIFIED BY TRANSCRIPTOME PROFILING: REMODL‐B

2017-06-01

Abstract excerpt

Background: DLBL subtypes identified by patterns of gene expression correspond to germinal center (GCB) or activated (ABC) B-cells like. The latter demonstrate dysregulation of the NF-KB pathway. Outcomes of treatment with R-CHOP are inferior for ABC DLBL in retrospective series. This study investigated whether adding bortezomib (B), a putative NF-KB inhibitor, can reverse this phenotype. Methods: The REMoDL-B stu...

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Lymphoma Diagnosis and Treatment

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Literature Corpus work: 4c1b8cf4-a4ce-5c32-b4d6-74e6e9109cae
DOI: 10.1002/hon.2437_120

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DIFFERENTIAL EFFICACY OF BORTEZOMIB IN SUBTYPES OF DIFFUSE LARGE B‐CELL LYMPHOMA (DLBL): a PROSPECTIVE RANDOMISED STUDY STRATIFIED BY TRANSCRIPTOME PROFILING: REMODL‐BDOI 10.1002/hon.2437_120Read

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