Article

Differential Roles of PFDN5 Isoforms in Head and Neck Squamous Cell Carcinoma: Insights from Proximity Interactome Mapping

2026-05-11

Abstract excerpt

<h4>ABSTRACT</h4> Head and neck squamous cell carcinoma (HNSCC) ranks as the seventh most common cancer, with increasing incidence and mortality rates and limited therapeutic progress. The heterohexameric prefoldin complex, a highly conserved co-chaperone assembly composed of six PFDN subunits, exhibits expression levels strongly correlated with cancer progression. Among these subunits, the PFDN5 gene presents a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4bae86ff-db4c-5f1e-b6fd-ceb8288c84c5
DOI: 10.64898/2026.05.07.723477

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differential Roles of PFDN5 Isoforms in Head and Neck Squamous Cell Carcinoma: Insights from Proximity Interactome MappingDOI 10.64898/2026.05.07.723477Read

SPINK5 is a Prognostic Biomarker Associated With the Progression and Prognosis of Laryngeal Squamous Cell Carcinoma Identified by Weighted Gene Co-Expression Network AnalysisSemantic proximity Read

Identification of Prognostic Biomarkers and Independent Indicators Among PFDN1/2/3/4/5/6 in Liver Hepatocellular CarcinomaSemantic proximity Read

KLF5 regulates actin remodeling to enhance the metastasis of nasopharyngeal carcinomaSemantic proximity Read

PHF5A regulates the expression of the DOCK5 variant to promote HNSCC progression through p38 MAPK activationSemantic proximity Read

Prognostic Role of DFNA5 in Head and Neck Squamous Cell Carcinoma Revealed by Systematic Expression AnalysisSemantic proximity Read

A Functional Reference Map of RNF8 Interactome in CancersSemantic proximity Read

The RNA-binding protein La/SSB drives head and neck squamous cell carcinoma progression through TFAP2C-mediated transcriptional activation of FSCN1Semantic proximity Read

Prediction of the Potential Efficacy of Dlx5 in Immunotherapy for Hypopharyngeal Cancer through Integrated Bulk and Single-Cell RNA SequencingSemantic proximity Read

Distinct co-expression networks using multi-omic data reveal novel interventional targets in HPV-positive and negative head-and-neck squamous cell cancerSemantic proximity Read

Identification of the LNC02362–EFNA5 axis as a Potential Prognosis Biomarker in Hepatocellular Carcinoma via Comprehensive Bioinformatics AnalysisSemantic proximity Read

Proximity labeling reveals a new <i>in vivo</i> network of interactors for the histone demethylase KDM5Semantic proximity Read

RNA-Binding Motif Protein 3 as a Therapeutic and Prognostic Target for Drug DiscoverySemantic proximity Read