Article

TGF-β inhibitor accelerates BMP4-induced cochlear gap junction formation during <i>in vitro</i> differentiation of embryonic stem cells

2020-02-17

Abstract excerpt

Mutations in the connexin 26 (CX26)/gap junction beta-2 ( GJB2 ) gene are the most frequent cause of hereditary deafness worldwide. Using mouse induced pluripotent stem cells (iPSCs) and a BMP4 signal-based floating and adherent culture system, we recently produced in vitro responsible for GJB2 -related deafness (CX26-gap junction plaque-forming cells, CX26GJCs). However, to use these cells as a disease model p...

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Literature Corpus work: 4b67ff84-538d-5b62-88c1-946462cb32e1
DOI: 10.1101/2020.02.17.952481

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