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Article

Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functions.

Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2005

Zhang Yanping, Tang Wenxue, Ahmad Shoab, Sipp James A, Chen Ping, Lin Xi

Abstract excerpt

Dysfunction of gap junctions (GJs) caused by mutations in connexin26 (Cx26) and Cx30 accounts for nearly half of all cases of hereditary nonsyndromic deafness cases. Although it is widely held that GJs connecting supporting cells in the organ of Corti mainly provide ionic pathways for rapid removal of K+ around the base of hair cells, the function of GJs in the cochlea remains unknown. Here we show that GJs were...

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Identifiers

PMID: 16217030
DOI: 10.1073/pnas.0501859102
PMCID: PMC1257692

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