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Epithelial Cell Line Derived from Endometriotic Lesion Mimics Macrophage Nervous Mechanism of Pain Generation on Proteome and Metabolome Levels.

Biomolecules - 17 Aug 2021

Neuditschko Benjamin, Leibetseder Marlene, Brunmair Julia, Hagn Gerhard, Skos Lukas, Gerner Marlene C, Meier-Menches Samuel M, Yotova Iveta, Gerner Christopher

Abstract excerpt

Endometriosis is a benign disease affecting one in ten women of reproductive age worldwide. Although the pain level is not correlated to the extent of the disease, it is still one of the cardinal symptoms strongly affecting the patients' quality of life. Yet, a molecular mechanism of this pathology, including the formation of pain, remains to be defined. Recent studies have indicated a close interaction between...

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PMID: 34439896
DOI: 10.3390/biom11081230
PMCID: PMC8393596

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