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Article

Spatial transcriptomic analysis identifies epithelium-macrophage crosstalk in endometriotic lesions

10 Jan 2025

Abstract excerpt

The mechanisms underlying the pathophysiology of endometriosis, characterized by the presence of endometrium-like tissue outside the uterus, remain poorly understood. This study aimed to identify cell type-specific gene expression changes in superficial peritoneal endometriotic lesions and elucidate the crosstalk among the stroma, epithelium, and macrophages compared to patient-matched eutopic endometrium....

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PMID: 39935459
DOI: 10.1016/j.isci.2025.111790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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