Article

Thousands of missing variants in the UK BioBank are recoverable by genome realignment

2019-12-10

Abstract excerpt

The UK Biobank is an unprecedented resource for human disease research. In March 2019, 49,997 exomes were made publicly available to investigators. Here we note that thousands of variant calls are unexpectedly absent from the current dataset, with 641 genes showing zero variation. We show that the reason for this was an erroneous read alignment to the GRCh38 reference. The missing variants can be recovered by modi...

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Literature Corpus work: 4af8ca56-73eb-5c54-9380-d16c5e6e668e
DOI: 10.1101/868570

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