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Article

Impact of functional ABCG2 polymorphisms on the adverse effects of gefitinib in Japanese patients with non-small-cell lung cancer.

Cancer chemotherapy and pharmacology - 1 Sept 2010

Akasaka Keiichi, Kaburagi Takayuki, Yasuda Shin'ichi, Ohmori Kyoko, Abe Kaori, Sagara Hironori, Ueda Yoshihiko, Nagao Koshu, Imura Johji, Imai Yasuo

Abstract excerpt

PURPOSE: ABCG2 is a half-size ATP-binding cassette transporter implicated in cellular gefitinib transport. Reportedly, the c.421C > A ABCG2 gene polymorphism was associated with gefitinib-induced diarrhea in Caucasian patients with non-small-cell lung cancer. Since c.421C > A ABCG2, resulting in p.Q141K substitution, is more prevalent in Asian populations, the putative relationship between gefitinib-induced...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Source

Identifiers

PMID: 20035425
DOI: 10.1007/s00280-009-1211-6

Genes

ABCG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Impact of functional ABCG2 polymorphisms on the adverse effects of gefitinib in Japanese patients with non-small-cell lung cancer.PMID 20035425Read ↗

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