Article

Adenovirus with DNA Packaging Gene Mutations Increased Virus Release

2016-12-19

Abstract excerpt

Adenoviruses (Ads) have been extensively manipulated for the development of cancer selective replication, leading to cancer cell death or oncolysis. Clinical studies using E1-modified oncolytic Ads have shown that this therapeutic platform was safe, but with limited efficacy, indicating the necessity of targeting other viral genes for manipulation. To improve the therapeutic efficacy of oncolytic Ads, we treated t...

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Literature Corpus work: 4ac08f14-625b-53b1-a28d-65077b6085d8
DOI: 10.20944/preprints201612.0098.v1

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