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Article

Adenovirus with DNA Packaging Gene Mutations Increased Virus Release.

Viruses - 20 Dec 2016

Wechman Stephen L, Rao Xiao-Mei, McMasters Kelly M, Zhou Heshan Sam

Abstract excerpt

Adenoviruses (Ads) have been extensively manipulated for the development of cancer selective replication, leading to cancer cell death or oncolysis. Clinical studies using E1-modified oncolytic Ads have shown that this therapeutic platform was safe, but with limited efficacy, indicating the necessity of targeting other viral genes for manipulation. To improve the therapeutic efficacy of oncolytic Ads, we treated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27999391
DOI: 10.3390/v8120333
PMCID: PMC5192394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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