Article

A positive feedback cycle between the alarmin S100A8/A9 and NLRP3 inflammasome-GSDMD signalling reinforces the innate immune response in Candida albicans keratitis

2023-04-18

Abstract excerpt

<h4>Background: </h4> Fungal keratitis is a severe sight-threatening ocular infection, without effective treatment strategies available now. Calprotectin S100A8/A9 has recently attracted great attention as a critical alarmin modulating the innate immune response against microbial challenges. However, the unique role of S100A8/A9 in fungal keratitis is poorly understood. <h4>Methods: </h4> Experimental fungal kerat...

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Literature Corpus work: 4ab6e897-b1d1-5f71-95ac-8cfc503bd3a0
DOI: 10.21203/rs.3.rs-2807590/v1

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