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Article

Role of Sclerostin in Cardiovascular System

9 May 2025

Abstract excerpt

Sclerostin, encoded by the SOST gene, is a novel bone anabolic target for bone diseases. Humanized anti-sclerostin antibody, romosozumab, was approved for treatment of postmenopausal osteoporosis by the US Food and Drug Administration (FDA), but with a black-box warning on cardiovascular risk. The clinical data regarding cardiovascular events from various pre-marketing and post-marketing studies of romosozumab...

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PMID: 40429697
DOI: 10.3390/ijms26104552

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