Article

Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice

2024-12-28

Abstract excerpt

<h4>Introduction</h4> In USA, six million individuals with Sub-Saharan ancestry carry two APOL1 high-risk variants, which increase the risk for kidney diseases. Whether APOL1 high-risk variants are independent risk factors for cardiovascular diseases is unclear and requires further investigation. <h4>Methods</h4> We characterized a mouse model to investigate the role of APOL1 in dyslipidemia and cardiovascular...

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Literature Corpus work: 49ee38f6-9c7e-5996-a453-f19e8cc1894d
DOI: 10.1101/2024.12.28.630625

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