Article

Preeclampsia in mice carrying fetuses with APOL1 risk variants

2024-03-21

Abstract excerpt

African-American women have a maternal mortality rate approximately three times higher than European-American women. This is partially due to hypertensive disorders of pregnancy, including preeclampsia. Fetal APOL1 high-risk genotype increases preeclampsia risk, although mechanisms remain elusive. We characterized two mouse models to investigate whether fetal-origin APOL1 induces preeclampsia and which cell types...

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Literature Corpus work: bb796612-f985-5879-aeca-6a7df61448f7
DOI: 10.1101/2024.03.20.586039

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