Article
Liver Sinusoidal Endothelial Cells and Laminin dictate cholangiocytes’ fate in chronic liver disease
2024-10-01
Abstract excerpt
<h4>Summary</h4> In chronic liver disease (CLD), hepatocyte senescence limits conventional regeneration, prompting an alternative regeneration mechanism through transdifferentiation of reactive cholangiocytes (or ductular reaction cells - DRs). Yet, this alone is insufficient to avoid liver failure and transplantation, highlighting the importance of a deeper understanding of the mechanism. We focused on the DRs m...
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Identifiers and source
- Literature Corpus work
- 494ccdfd-b42e-59dd-8eb3-343e8fc48ad2
- DOI
- 10.1101/2024.09.29.615650