Article

DeltaNMF: A Two-Stage Neural NMF for Differential Gene Program Discovery

2026-01-24

Abstract excerpt

Non-negative matrix factorization (NMF) is a foundational dimensionality-reduction method in single-cell transcriptomics, valued for its interpretable gene programs. However, in case-control settings common in perturbation and disease research, standard NMF conflates quantitative shifts in program usage with qualitative emergence of novel programs, obscuring whether observed differences reflect altered activity of...

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Literature Corpus work: 4933ff5b-a39b-5bba-b1d8-161061642256
DOI: 10.64898/2026.01.22.701049

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