Article

Scalable Non-negative Matrix Factorization of the Human Cell Census Reveals Interpretable Transcriptional Programs

2025-12-31

Abstract excerpt

Large single-cell atlases now span tens of millions of cells, yet few provide reusable and interpretable reference representations that support direct biological reasoning at atlas-scale. Here, we present an interpretable Non-negative Matrix Factorization reference embedding of 28.5 million healthy cells and approximately 60,000 genes from the Human Cell Census. The resulting gene and cell weights define additive...

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Literature Corpus work: 96785b01-5eab-51b3-b5fd-c1e30f813b89
DOI: 10.64898/2025.12.30.697085

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