Article

CD155/PVR as a determinant of anti-HER2 therapy sensitivity in breast cancer

2025-11-14

Abstract excerpt

<title>Abstract</title> <p> CD155 (poliovirus receptor, PVR) is frequently overexpressed across cancers and has been associated with tumor progression, poor prognosis, and therapy resistance. Here, we identify CD155 as a modulator of HER2-targeted monoclonal antibody efficacy. Analysis of clinical datasets revealed that high CD155 expression correlates with overall, progression-free, and disease-specific surviva...

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Literature Corpus work: 48ec52a6-580c-587f-95d8-9ff3a2413a01
DOI: 10.21203/rs.3.rs-7994408/v1

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