Article

The Molecular Human – A Roadmap of Molecular Interactions Linking Multiomics Networks with Disease Endpoints

2022-11-03

Abstract excerpt

In-depth multiomics phenotyping can provide a molecular understanding of complex physiological processes and their pathologies. Here, we report on the application of 18 diverse deep molecular phenotyping (omics-) technologies to urine, blood, and saliva samples from 391 participants of the multiethnic diabetes study QMDiab. We integrated quantitative readouts of 6,304 molecular traits with 1,221,345 genetic varian...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 489b55a1-2b38-5415-a6c2-b24677fbf42e
DOI: 10.1101/2022.10.31.22281758

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Molecular Human – A Roadmap of Molecular Interactions Linking Multiomics Networks with Disease EndpointsDOI 10.1101/2022.10.31.22281758Read

A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes.Semantic proximity Read

Predicting type 2 diabetes via machine learning integration of multiple omics from human pancreatic islets.Semantic proximity Read

An atlas of genetic scores to predict multi-omic traitsSemantic proximity Read

Genetic and environmental correlations between complex phenotypes differ by race/ethnicity and sexSemantic proximity Read

An atlas of genetic scores to predict multi-omic traits.Semantic proximity Read

Uncovering genetic associations in the human diseasome using an endophenotype-augmented disease networkSemantic proximity Read

Integrative multi-omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for Attention-Deficit/Hyperactivity DisorderSemantic proximity Read

Context-dependent molecular responses to heterogeneous metabolic disease traitsSemantic proximity Read

Next-generation epidemiology: the role of high-resolution molecular phenotyping in diabetes research.Semantic proximity Read

Correlations between complex human phenotypes vary by genetic background, gender, and environment.Semantic proximity Read

Integrative multi‐omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for Attention‐Deficit /Hyperactivity DisorderSemantic proximity Read

Integrative Analysis of Multi-omics Data for Discovery and Functional Studies of Complex Human Diseases.Semantic proximity Read