Article

Pharmacological Immunomodulation by Collagen-Polyvinylpyrrolidone or Pirfenidone Plays a Role in the Recovery of Patients with Severe COVID-19, Through a Similar Mechanism of Action Involving the JAK-STAT Signaling Pathway. Pilot Study

2025-06-04

Abstract excerpt

The therapeutic target of COVID-19 is focused on controlling inflammation and preventing fibrosis. Collagen-polyvinylpyrrolidone (collagen-PVP) and pirfenidone have the ability to control the cytokine storms observed in rheumatic and fibrotic disorders. Here, we explore separately their therapeutic effects on the early treatment of 26 patients with severe COVID-19, compared to 10 controls treated with dexamethason...

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Literature Corpus work: 4895a379-f3c5-5b2a-a210-645a7c0ce024
DOI: 10.20944/preprints202506.0007.v1

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Pharmacological Immunomodulation by Collagen-Polyvinylpyrrolidone or Pirfenidone Plays a Role in the Recovery of Patients with Severe COVID-19, Through a Similar Mechanism of Action Involving the JAK-STAT Signaling Pathway. Pilot StudyDOI 10.20944/preprints202506.0007.v1Read

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