Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancers

8 May 2014

Abstract excerpt

// Chong-kui Sun 1,2,* , Fan Zhang 1,* , Tao Xiang 1 , Qianming Chen 2 , Tej K. Pandita 3 , Yuping Huang 4 , Mickey C.T. Hu 5 and Qin Yang 1 1 Cancer Biology Division, Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO 63108 2 State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China 3 Department of Radiation Oncology, UT Southwestern, Dallas, TX...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24831086
DOI: 10.18632/oncotarget.1952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancersPMID 24831086Read ↗

S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repairSemantic proximity Read ↗

Aberrant modulation of ribosomal protein S6 phosphorylation confers acquired resistance to MAPK pathway inhibitors in BRAF-mutant melanoma.Semantic proximity Read ↗

Targeting S6K/NFκB/SQSTM1/Polθ signaling to suppress radiation resistance in prostate cancerSemantic proximity Read ↗

Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation.Semantic proximity Read ↗

Simultaneous Targeting of RSK and AKT Efficiently Inhibits YB-1-Mediated Repair of Ionizing Radiation-Induced DNA Double-Strand Breaks in Breast Cancer Cells.Semantic proximity Read ↗

Molecularly targeting the PI3K-Akt-mTOR pathway can sensitize cancer cells to radiotherapy and chemotherapySemantic proximity Read ↗

The role of the p90 ribosomal S6 kinase family in prostate cancer progression and therapy resistanceSemantic proximity Read ↗

Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancerSemantic proximity Read ↗

Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.Semantic proximity Read ↗

Targeting autophagy reverses de novo resistance in homologous recombination repair proficient breast cancers to PARP inhibitionSemantic proximity Read ↗

DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1Semantic proximity Read ↗

Disruption of the ribosomal P complex leads to stress-induced autophagy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.