Back to search

Article

Superior antibody immunogenicity of a RH5 blood-stage malaria vaccine in Tanzanian infants as compared to adults

2023-04-20

Abstract excerpt

<h4>Background</h4> RH5 is the leading blood-stage candidate antigen for inclusion in a Plasmodium falciparum malaria vaccine, however, its safety profile and ability to induce functional immune responses in a malaria-endemic population are unknown. Characterising safety and immunogenicity is key to refine and progress next-generation RH5-based blood-stage malaria vaccines to field efficacy assessment. <h4>Methods...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4780300a-10d1-5013-9fdd-42a0f1fe8107
DOI
10.1101/2023.04.17.23288686
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Superior antibody immunogenicity of a RH5 blood-stage malaria vaccine in Tanzanian infants as compared to adultsDOI 10.1101/2023.04.17.23288686
Safety and efficacy of the blood-stage malaria vaccine RH5.1/Matrix-M in Burkina Faso: interim results of a double-blind, randomised, controlled phase 2b trial in childrenSemantic proximity
B and T cell responses to pre-erythrocytic R21/Matrix-M and blood-stage RH5.1/Matrix-M malaria vaccines in endemic settingsSemantic proximity
Current Developments in Malaria Vaccination: A Concise Review on Implementation, Challenges, and Future DirectionsSemantic proximity
Extended safety, immunogenicity and efficacy of a blood-stage malaria vaccine in malian children: 24-month follow-up of a randomized, double-blinded phase 2 trial.Semantic proximity
Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody ClonotypeSemantic proximity
Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotypeSemantic proximity
Genotypic analysis of RTS,S/AS01E malaria vaccine efficacy against parasite infection as a function of dosage regimen and baseline malaria infection status in children aged 5-17 months in Ghana and Kenya: a longitudinal phase 2b randomised controlled trial.Semantic proximity
Dose-sparing self-amplifying RNA vaccine induces high functional antibodies to blood-stage <i>Plasmodium falciparum</i> malariaSemantic proximity
Multi-functional antibodies are induced by the RTS,S malaria vaccine and associated with protection in a phase I/IIa trialSemantic proximity
Longitudinal IgG antibody responses to <i>Plasmodium vivax</i> blood-stage antigens during and after acute vivax malaria in individuals living in the Brazilian AmazonSemantic proximity
Delayed booster dosing improves human antigen-specific Ig and B cell responses to the RH5.1/AS01<sub>B</sub> malaria vaccineSemantic proximity
Towards a multi-antigen multi-stage malaria vaccineSemantic proximity
Select a neighboring publication to make it the new centre.