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Article

p53 Family in Resistance to Targeted Therapy of Melanoma.

International journal of molecular sciences - 21 Dec 2022

Vlašić Ignacija, Horvat Anđela, Tadijan Ana, Slade Neda

Abstract excerpt

Metastatic melanoma is one of the most aggressive tumors, with frequent mutations affecting components of the MAPK pathway, mainly protein kinase BRAF. Despite promising initial response to BRAF inhibitors, melanoma progresses due to development of resistance. In addition to frequent reactivation of MAPK or activation of PI3K/AKT signaling pathways, recently, the p53 pathway has been shown to contribute to...

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Share to Cell Line, Tumor
Share to Drug Resistance, Neoplasm
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Melanoma

Share to Phosphatidylinositol 3-Kinases

Share to Protein Kinase Inhibitors

Share to Proto-Oncogene Proteins B-raf

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 36613518
DOI: 10.3390/ijms24010065
PMCID: PMC9820688

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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