Article

CharacTERT: A Machine Learning Tool for Classifying hTERT Missense Variants

2026-05-20

Abstract excerpt

Missense mutations in TERT , the gene encoding the human telomerase catalytic subunit hTERT, are associated with Telomere Biology Disorders (TBDs). Experimentally elucidating the effects of all possible missense variants would be time-consuming and technically challenging. Moreover, current computational predictors are not hTERT-specific and primarily rely on sequence information, failing to capture the complex b...

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Literature Corpus work: 4643dfa9-1ddb-5438-866e-f2251da2d996
DOI: 10.64898/2026.05.18.725793

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