Article

Smad6-Mediated Suppression of TGF-β/BMP Signaling Facilitates Oocyte Extract-Induced Reprogramming

2025-11-20

Abstract excerpt

<title>Abstract</title> <p>Stem cells serve as foundational seed cells in regenerative medicine, yet their limited availability remains a significant constraint. The emergence of somatic cell reprogramming has provided a promising alternative for generating pluripotent stem cells. However, challenges such as low efficiency, unpredictable outcomes, and safety concerns persist, largely due to an incomplete understa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4625b604-f640-5eb1-ba25-1afed456d714
DOI: 10.21203/rs.3.rs-7671439/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Smad6-Mediated Suppression of TGF-β/BMP Signaling Facilitates Oocyte Extract-Induced ReprogrammingDOI 10.21203/rs.3.rs-7671439/v1Read

SMAD4 Feedback Activates The Canonical TGF-β Family Signaling PathwaysSemantic proximity Read

Activin/nodal signalling controls the epigenome and epitranscriptome of human pluripotent stem cellsSemantic proximity Read

Reprogramming of fish somatic cells for nuclear transfer is primed by <i>Xenopus</i> egg extractSemantic proximity Read

Reprogramming of fish somatic cells for nuclear transfer is primed by Xenopus egg extractSemantic proximity Read

LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signalingSemantic proximity Read

Transcriptomic landscape reveals germline potential of porcine skin-derived multipotent dermal fibroblast progenitorsSemantic proximity Read

A comprehensive transcriptomic view on the role of SMAD4 gene by RNAi-mediated knockdown in porcine follicular granulosa cellsSemantic proximity Read

TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cellsSemantic proximity Read

Gatekeeper transcription factors regulate switch between lineage preservation and cell plasticitySemantic proximity Read

The Function and Regulation of BMP6 in Various Kinds of Stem CellsSemantic proximity Read

NANOG Is a Direct Target of TGFβ/Activin-Mediated SMAD Signaling in Human ESCsSemantic proximity Read

Biochemical Principles of SMAD Signaling Across the Animal KingdomSemantic proximity Read