Article

Src-dependent DBL family members drive resistance to vemurafenib in human melanoma

2019-02-26

Abstract excerpt

<h4>ABSTRACT</h4> The use of selective BRAF inhibitors (BRAFi) has produced remarkable outcomes for patients with advanced cutaneous melanoma harboring a BRAF V600E mutation. Unfortunately, the majority of patients eventually develop drug-resistant disease. We employed a genetic screening approach to identify gain-of-function mechanisms of BRAFi resistance in two independent melanoma cell lines. Our screens iden...

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Literature Corpus work: 4607b012-e2d0-508d-8564-af135cbbce4c
DOI: 10.1101/561597

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