Article
Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma.
Cancer discovery - 1 Feb 2013
Girotti Maria R, Pedersen Malin, Sanchez-Laorden Berta, Viros Amaya, Turajlic Samra, Niculescu-Duvaz Dan, Zambon Alfonso, Sinclair John, Hayes Andrew, Gore Martin, Lorigan Paul, Springer Caroline, Larkin James, Jorgensen Claus, Marais Richard
Abstract excerpt
UNLABELLED: We generated cell lines resistant to BRAF inhibitors and show that the EGF receptor (EGFR)-SRC family kinase (SFK)-STAT3 signaling pathway was upregulated in these cells. In addition to driving proliferation of resistant cells, this pathway also stimulated invasion and metastasis. EGFR inhibitors cooperated with BRAF inhibitors to block the growth of the resistant cells in vitro and in vivo, and...
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