Article
Detecting mechanisms of acquired BRAF inhibitor resistance in melanoma.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Lo Roger S, Shi Hubing
Abstract excerpt
(V600)BRAF mutation was identified as an ideal target for clinical therapy due to its indispensable roles in supporting melanoma initiation and progression. Despite the fact that BRAF inhibitors (BRAFi) can elicit anti-tumor responses in the majority of treated patients and confer overall survival benefits, acquired drug resistance is a formidable obstacle to long-term management of the disease. Several aberrant...
Topics
- Base Sequence
- DNA Mutational Analysis
- Drug Resistance, Neoplasm
- GTP Phosphohydrolases
- Humans
- Melanoma
- Membrane Proteins
- Mitogen-Activated Protein Kinase Kinases
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction