Article

GeneLLM: A large language model-based framework reveals age-dependent transcriptomic heterogeneity in sepsis diagnosis

2026-05-29

Abstract excerpt

<title>Abstract</title> <p>Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection (Sepsis-3 definition). It is highly heterogeneous and life-threatening, with marked age-dependent differences in host immune responses. However, whether such biological heterogeneity limits the performance and generalizability of transcriptomics-based diagnostic models remains...

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Literature Corpus work: 45582522-af58-5ab2-b389-1a2db20abc8f
DOI: 10.21203/rs.3.rs-9546779/v1

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