Article

IFN-γ induces epithelial-to-mesenchymal transition of cancer cells via an unique microRNA processing

2018-06-25

Abstract excerpt

<h4>ABSTRACT</h4> Interferon-γ (IFNγ) is a potent cytokine in modulating tumor immunity and tumoricidal effects. We demonstrate a new function of IFNγ in inducing epithelial-to-mesenchymal transition (EMT) in normal and cancer cells from different cell types. IFNγ activates JAK-STAT signaling pathway leading to the transcription of IFN-stimulated genes (ISGs), such as interferon-induced tetratricopeptide repeat 5...

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Literature Corpus work: 453d920c-9115-5301-ad11-77ed9c3d49c4
DOI: 10.1101/355263

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