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Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion

2021-09-19

Abstract excerpt

<h4>ABSTRACT</h4> 15% of colorectal cancers (CRC) cells exhibit a mucin hypersecretory phenotype, which is suggested to provide resistance to immune surveillance and chemotherapy. We now formally show that colorectal cancer cells build a barrier to chemotherapeutics by increasing mucins’ secretion. We show that low levels of KChIP3, a negative regulator of mucin secretion (Cantero-Recasens et al ., 2018), is a r...

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Identifiers and source

Literature Corpus work
44c825b7-b3a2-5ede-ad24-912dd9549140
DOI
10.1101/2021.09.17.460827
Open publication

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Reversing chemorefraction in colorectal cancer cells by controlling mucin secretionDOI 10.1101/2021.09.17.460827
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