Article

Evaluation of folliculin detection by immunohistochemistry in Birt-Hogg-Dubé associated kidney tumors

2022-06-02

Abstract excerpt

Germline inactivating mutations in folliculin (FLCN) cause Birt–Hogg–Dubé (BHD) syndrome, a rare autosomal dominant disorder predisposing to kidney tumors. Kidney tumors associated with BHD typically lack FLCN expression due to loss of heterozygosity. In this study we assessed the potential of four commercial anti-FLCN antibodies for immunohistochemistry, as currently no routine diagnostic FLCN stainings are perfo...

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Literature Corpus work: 4497d40d-8199-55db-913c-fab0e881f0e1
DOI: 10.1101/2022.06.01.494402

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